This session highlights groundbreaking developments in mooring technology, design optimization, and integrity management in the offshore industry. Presentations span the full lifecycle of mooring systems—from conceptual design and installation to real-time monitoring, inspection, and replacement. Presentations include industry’s first full mooring system replacement on a deepwater spar in the Gulf of Mexico, demonstrating innovative offshore execution and life-extension strategies; exploration of the next generation of FPSO hull and marine systems designed to enable remote or unmanned operations, supported by new hull concepts that minimize manual inspection and maintenance. Advancements in digital twins and data-driven modeling are highlighted through a hybrid digital twin approach for predicting mooring line fatigue, merging motion-based simulations with machine learning to improve cumulative damage estimation. Complementary studies examine extreme loads and fatigue mechanisms, including insights from scaled dynamic tank tests on out-of-plane (OPB) and in-plane (IPB) bending stresses, as well as the influence of biofouling on drag coefficients of mooring chains. The session also introduces innovative tools and methodologies—such as derivative-free optimization using surrogate modeling and an advanced ROV system for in-situ inspection and repair—to enhance mooring integrity, reliability, and operational safety in an increasingly digital and autonomous offshore environment.